L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy

• Main Authors: Zheng Jing (Author), Tomohiro Iba (Author), Hisamichi Naito (Author), Pingping Xu (Author), Jun-ichi Morishige (Author), Naoto Nagata (Author), Hironao Okubo (Author), Hitoshi Ando (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lenvatinib is an oral tyrosine kinase inhibitor that acts on multiple receptors involved in angiogenesis. Lenvatinib is a standard agent for the treatment of several types of advanced cancers; however, it frequently causes muscle-related adverse reactions. Our previous study revealed that lenvatinib...