Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

• Egile Nagusiak: Thean S. Chew (Egilea), Nuala R. O'Shea (Egilea), Gavin W. Sewell (Egilea), Stefan H. Oehlers (Egilea), Claire M. Mulvey (Egilea), Philip S. Crosier (Egilea), Jasminka Godovac-Zimmermann (Egilea), Stuart L. Bloom (Egilea), Andrew M. Smith (Egilea), Anthony W. Segal (Egilea)
• Formatua: Liburua
• Argitaratua: The Company of Biologists, 2015-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretion and confirm our previous findings, we perfo...