Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

• Main Authors: Thean S. Chew (Author), Nuala R. O'Shea (Author), Gavin W. Sewell (Author), Stefan H. Oehlers (Author), Claire M. Mulvey (Author), Philip S. Crosier (Author), Jasminka Godovac-Zimmermann (Author), Stuart L. Bloom (Author), Andrew M. Smith (Author), Anthony W. Segal (Author)
• Format: Book
• Published: The Company of Biologists, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretion and confirm our previous findings, we perfo...