Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

• Hoofdauteurs: Thean S. Chew (Auteur), Nuala R. O'Shea (Auteur), Gavin W. Sewell (Auteur), Stefan H. Oehlers (Auteur), Claire M. Mulvey (Auteur), Philip S. Crosier (Auteur), Jasminka Godovac-Zimmermann (Auteur), Stuart L. Bloom (Auteur), Andrew M. Smith (Auteur), Anthony W. Segal (Auteur)
• Formaat: Boek
• Gepubliceerd in: The Company of Biologists, 2015-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretion and confirm our previous findings, we perfo...