Nanofat lysate ameliorates pain and cartilage degradation of osteoarthritis through activation of TGF-β-Smad2/3 signaling of chondrocytes

• Main Authors: Yanzhi Ge (Author), Wenting Xu (Author), Zuxiang Chen (Author), Haiyan Zhang (Author), Wenbo Zhang (Author), Junjie Chen (Author), Jiefeng Huang (Author), Wenxi Du (Author), Peijian Tong (Author), Letian Shan (Author), Li Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Nanofat is an effective cell therapy for osteoarthritis (OA). However, it has clinical limitations due to its short half-life. We developed Nanofat lysate (NFL) to overcome the defect of Nanofat and explore its anti-OA efficacy and mechanism.Methods: Monoiodoacetate (MIA) was employed...