Nanofat lysate ameliorates pain and cartilage degradation of osteoarthritis through activation of TGF-β-Smad2/3 signaling of chondrocytes

• المؤلفون الرئيسيون: Yanzhi Ge (مؤلف), Wenting Xu (مؤلف), Zuxiang Chen (مؤلف), Haiyan Zhang (مؤلف), Wenbo Zhang (مؤلف), Junjie Chen (مؤلف), Jiefeng Huang (مؤلف), Wenxi Du (مؤلف), Peijian Tong (مؤلف), Letian Shan (مؤلف), Li Zhou (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Introduction: Nanofat is an effective cell therapy for osteoarthritis (OA). However, it has clinical limitations due to its short half-life. We developed Nanofat lysate (NFL) to overcome the defect of Nanofat and explore its anti-OA efficacy and mechanism.Methods: Monoiodoacetate (MIA) was employed...