A novel peroxisome proliferator-activated receptor gamma ligand improves insulin sensitivity and promotes browning of white adipose tissue in obese mice

• Glavni autori: Dan Wu (Autor), Venkateswararao Eeda (Autor), Ram Babu Undi (Autor), Shivani Mann (Autor), Michael Stout (Autor), Hui-Ying Lim (Autor), Weidong Wang (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2021-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Objective: Nuclear receptor Peroxisome Proliferator-Activated Receptor γ (PPARγ) is a promising target for the treatment of type 2 diabetes. The antidiabetic drug thiazolidinediones (TZDs) are potent insulin sensitizers as full agonists of PPARγ, but cause unwanted side effects. Recent discoveries h...