Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4

• Hlavní autoři: Yang-Yang Zhao (Autor), Dong-Ming Wu (Autor), Miao He (Autor), Feng Zhang (Autor), Ting Zhang (Autor), Teng Liu (Autor), Jin Li (Autor), Li Li (Autor), Ying Xu (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Acute liver injury (ALI) is associated with poor survival in patients with sepsis. During sepsis, the liver is the main site of bacterial endotoxin-induced inflammation. Lipopolysaccharide (LPS) promotes caspase-4/5/11 activation, leading to pyroptosis, a major sepsis driver. This study aimed to ide...