Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma

• Main Authors: Melanie J. Mittenbühler (Author), Hans-Georg Sprenger (Author), Sabine Gruber (Author), Claudia M. Wunderlich (Author), Lara Kern (Author), Jens C. Brüning (Author), F. Thomas Wunderlich (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The current obesity pandemic represents a major health burden, given that it predisposes to the development of numerous obesity-associated disorders. The obesity-derived adipokines not only impair systemic insulin action but also increase the incidence of hepatocellular carcinoma (HCC), a...