Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma

• Hoofdauteurs: Melanie J. Mittenbühler (Auteur), Hans-Georg Sprenger (Auteur), Sabine Gruber (Auteur), Claudia M. Wunderlich (Auteur), Lara Kern (Auteur), Jens C. Brüning (Auteur), F. Thomas Wunderlich (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2018-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Objective: The current obesity pandemic represents a major health burden, given that it predisposes to the development of numerous obesity-associated disorders. The obesity-derived adipokines not only impair systemic insulin action but also increase the incidence of hepatocellular carcinoma (HCC), a...