Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway

• Main Authors: Yingquan Liang (Author), Guilan Chen (Author), Feng Zhang (Author), Xiaoxiao Yang (Author), Yuanli Chen (Author), Yajun Duan (Author), Maoyun Yu (Author), Shuang Zhang (Author), Jihong Han (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular calcification is strongly associated with atherosclerotic plaque burden and plaque instability. The activation of extracellular signal-regulated kinase 1/2 (ERK1/2) increases runt related transcription factor 2 (RUNX2) expression to promote vascular calcification. Procyanidin B2 (PB2), a po...