Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson's Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice

• Main Authors: Andrea Casiraghi (Author), Francesca Longhena (Author), Gaia Faustini (Author), Giovanni Ribaudo (Author), Lorenzo Suigo (Author), Gisela Andrea Camacho-Hernandez (Author), Federica Bono (Author), Viviana Brembati (Author), Amy Hauck Newman (Author), Alessandra Gianoncelli (Author), Valentina Straniero (Author), Arianna Bellucci (Author), Ermanno Valoti (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is characterized by dopaminergic nigrostriatal neurons degeneration and Lewy body pathology, mainly composed of α-synuclein (αSyn) fibrillary aggregates. We recently described that the neuronal phosphoprotein Synapsin III (Syn III) participates in αSyn pathology in PD b...