Relating Molecular Dynamics Simulations to Functional Activity for Gly-Rich Membranolytic Helical Kiadin Peptides

• Main Authors: Tomislav Rončević (Author), Matko Maleš (Author), Yogesh Sonavane (Author), Filomena Guida (Author), Sabrina Pacor (Author), Alessandro Tossi (Author), Larisa Zoranić (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Kiadins are in silico designed peptides with a strong similarity to <i>di</i>PGLa-H, a tandem sequence of PGLa-H (KIAKVALKAL) and with single, double or quadruple glycine substitutions. They were found to show high variability in their activity and selectivity against Gram-negative and G...