Simulation and Machine Learning Methods for Ion-Channel Structure Determination, Mechanistic Studies and Drug Design

• Main Authors: Zhengdan Zhu (Author), Zhenfeng Deng (Author), Qinrui Wang (Author), Yuhang Wang (Author), Duo Zhang (Author), Ruihan Xu (Author), Lvjun Guo (Author), Han Wen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ion channels are expressed in almost all living cells, controlling the in-and-out communications, making them ideal drug targets, especially for central nervous system diseases. However, owing to their dynamic nature and the presence of a membrane environment, ion channels remain difficult targets f...