Simulation and Machine Learning Methods for Ion-Channel Structure Determination, Mechanistic Studies and Drug Design

• Auteurs principaux: Zhengdan Zhu (Auteur), Zhenfeng Deng (Auteur), Qinrui Wang (Auteur), Yuhang Wang (Auteur), Duo Zhang (Auteur), Ruihan Xu (Auteur), Lvjun Guo (Auteur), Han Wen (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Ion channels are expressed in almost all living cells, controlling the in-and-out communications, making them ideal drug targets, especially for central nervous system diseases. However, owing to their dynamic nature and the presence of a membrane environment, ion channels remain difficult targets f...