A CD3/CD28 microbead-based HIV-1 viral outgrowth assay

• मुख्य लेखकों: Yury V. Kuzmichev (लेखक), Rebecca T. Veenhuis (लेखक), Christopher W. Pohlmeyer (लेखक), Caroline C. Garliss (लेखक), Victoria E.K. Walker-Sperling (लेखक), Joel N. Blankson (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2017-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Aims: Latently infected resting CD4 T cells represent a major barrier to HIV-1 eradication efforts. The standard assays used for measuring this reservoir induce activation of resting CD4 T cells with either phytohaemagglutinin (PHA) with irradiated feeder cells, or with anti-CD3 antibodies. We desig...