A CD3/CD28 microbead-based HIV-1 viral outgrowth assay

• 主要な著者: Yury V. Kuzmichev (著者), Rebecca T. Veenhuis (著者), Christopher W. Pohlmeyer (著者), Caroline C. Garliss (著者), Victoria E.K. Walker-Sperling (著者), Joel N. Blankson (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2017-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Aims: Latently infected resting CD4 T cells represent a major barrier to HIV-1 eradication efforts. The standard assays used for measuring this reservoir induce activation of resting CD4 T cells with either phytohaemagglutinin (PHA) with irradiated feeder cells, or with anti-CD3 antibodies. We desig...