Variant‐based heritability assessment of dexmedetomidine and fentanyl clearance in pediatric patients

• Main Authors: Morgan L. Shannon (Author), Ayesha Muhammad (Author), Nathan T. James (Author), Michael L. Williams (Author), Joseph Breeyear (Author), Todd Edwards (Author), Jonathan D. Mosley (Author), Leena Choi (Author), Prince Kannankeril (Author), Sara Van Driest (Author)
• Format: Book
• Published: Wiley, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Despite complex pathways of drug disposition, clinical pharmacogenetic predictors currently rely on only a few high effect variants. Quantification of the polygenic contribution to variability in drug disposition is necessary to prioritize target drugs for pharmacogenomic approaches and gui...