Variant‐based heritability assessment of dexmedetomidine and fentanyl clearance in pediatric patients

• मुख्य लेखकों: Morgan L. Shannon (लेखक), Ayesha Muhammad (लेखक), Nathan T. James (लेखक), Michael L. Williams (लेखक), Joseph Breeyear (लेखक), Todd Edwards (लेखक), Jonathan D. Mosley (लेखक), Leena Choi (लेखक), Prince Kannankeril (लेखक), Sara Van Driest (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2023-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Despite complex pathways of drug disposition, clinical pharmacogenetic predictors currently rely on only a few high effect variants. Quantification of the polygenic contribution to variability in drug disposition is necessary to prioritize target drugs for pharmacogenomic approaches and gui...