Variant‐based heritability assessment of dexmedetomidine and fentanyl clearance in pediatric patients

• Главные авторы: Morgan L. Shannon (Автор), Ayesha Muhammad (Автор), Nathan T. James (Автор), Michael L. Williams (Автор), Joseph Breeyear (Автор), Todd Edwards (Автор), Jonathan D. Mosley (Автор), Leena Choi (Автор), Prince Kannankeril (Автор), Sara Van Driest (Автор)
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• Опубликовано: Wiley, 2023-09-01T00:00:00Z.
• Предметы: article
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Abstract Despite complex pathways of drug disposition, clinical pharmacogenetic predictors currently rely on only a few high effect variants. Quantification of the polygenic contribution to variability in drug disposition is necessary to prioritize target drugs for pharmacogenomic approaches and gui...