Increased Bone Marrow Uptake and Accumulation of Very-Late Antigen-4 Targeted Lipid Nanoparticles

• मुख्य लेखकों: Laura E. Swart (लेखक), Marcel H. A. M. Fens (लेखक), Anita van Oort (लेखक), Piotr Waranecki (लेखक), L. Daniel Mata Casimiro (लेखक), David Tuk (लेखक), Martijn Hendriksen (लेखक), Luca van den Brink (लेखक), Elizabeth Schweighart (लेखक), Cor Seinen (लेखक), Ryan Nelson (लेखक), Anja Krippner-Heidenreich (लेखक), Tom O'Toole (लेखक), Raymond M. Schiffelers (लेखक), Sander Kooijmans (लेखक), Olaf Heidenreich (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Lipid nanoparticles (LNPs) have evolved rapidly as promising delivery systems for oligonucleotides, including siRNAs. However, current clinical LNP formulations show high liver accumulation after systemic administration, which is unfavorable for the treatment of extrahepatic diseases, such as hemato...