Increased Bone Marrow Uptake and Accumulation of Very-Late Antigen-4 Targeted Lipid Nanoparticles

• Prif Awduron: Laura E. Swart (Awdur), Marcel H. A. M. Fens (Awdur), Anita van Oort (Awdur), Piotr Waranecki (Awdur), L. Daniel Mata Casimiro (Awdur), David Tuk (Awdur), Martijn Hendriksen (Awdur), Luca van den Brink (Awdur), Elizabeth Schweighart (Awdur), Cor Seinen (Awdur), Ryan Nelson (Awdur), Anja Krippner-Heidenreich (Awdur), Tom O'Toole (Awdur), Raymond M. Schiffelers (Awdur), Sander Kooijmans (Awdur), Olaf Heidenreich (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2023-05-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Lipid nanoparticles (LNPs) have evolved rapidly as promising delivery systems for oligonucleotides, including siRNAs. However, current clinical LNP formulations show high liver accumulation after systemic administration, which is unfavorable for the treatment of extrahepatic diseases, such as hemato...