Potential role of glutathione in evolution of thiol-based redox signaling sites in proteins

• Main Authors: Kaavya A Mohanasundaram (Author), Naomi L Haworth (Author), Mani P Grover (Author), Tamsyn M Crowley (Author), Andrzej eGoscinski (Author), Merridee Ann Wouters (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cysteine is susceptible to a variety of modifications by reactive oxygen and nitrogen oxide species, including glutathionylation; and when two cysteines are involved, disulfide formation. Glutathione-cysteine adducts may be removed from proteins by glutaredoxin, whereas disulfides may be reduced by...