Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

• Main Authors: Hong Li (Author), Jing Shen (Author), Tong Wu (Author), Jiangying Kuang (Author), Qinhui Liu (Author), Shihai Cheng (Author), Shiyun Pu (Author), Lei Chen (Author), Rui Li (Author), Yanping Li (Author), Min Zou (Author), Zhiyong Zhang (Author), Wei Jiang (Author), Aijuan Qu (Author), Jinhan He (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treated primary human hepatocytes, HepG2 cells, and Rhes...