Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity

• Main Authors: Vahid Jamshidi (Author), Seyed Ali Hashemi (Author), azadeh Khalili (Author), Parviz Fallah (Author), Mohammad Mahdi Ahmadian-Attari (Author), Leila Beikzadeh (Author), Roham Mazloom (Author), Parvaneh Najafizadeh (Author), Gholamreza Bayat (Author)
• Format: Book
• Published: Mashhad University of Medical Sciences, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The most important toxicity of acetaminophen is hepatotoxicity. Farnesoid X-activated receptors (FXR) are one of the nuclear receptor superfamily members which have a pivotal role in the bile acid regulation. The objective of the present study was to examine the role of FXR in mediating...