mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

• Main Authors: Copani Agata (Author), Traficante Anna (Author), Montana Michael C (Author), Chiechio Santina (Author), Zammataro Magda (Author), Nicoletti Ferdinando (Author), Gereau Robert W (Author)
• Format: Book
• Published: SAGE Publishing, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Group II metabotropic glutamate receptors (mGluRs) couple to the inhibitory G-protein Gi. The group II mGluRs include two subtypes, mGlu2 and mGlu3, and their pharmacological activation produces analgesic effects in inflammatory and neuropathic pain states. Howev...