mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

• 主要な著者: Copani Agata (著者), Traficante Anna (著者), Montana Michael C (著者), Chiechio Santina (著者), Zammataro Magda (著者), Nicoletti Ferdinando (著者), Gereau Robert W (著者)
• フォーマット: 図書
• 出版事項: SAGE Publishing, 2011-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

<p>Abstract</p> <p>Group II metabotropic glutamate receptors (mGluRs) couple to the inhibitory G-protein Gi. The group II mGluRs include two subtypes, mGlu2 and mGlu3, and their pharmacological activation produces analgesic effects in inflammatory and neuropathic pain states. Howev...