Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions

• Glavni autori: Joshuaine Grant (Autor), Fei Hua (Autor), Joshua F. Apgar (Autor), John M. Burke (Autor), Diana H. Marcantonio (Autor)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

ABSTRACTEarly assessment of dosing requirements should be an integral part of developability assessments for a discovery program. If a very high dose is required to achieve the desired pharmacological effect, it may not be clinically feasible or commercially desirable to develop the biotherapeutic f...