Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and α,β-unsaturated ketone group

• Päätekijät: Xiao-hui Gao (Tekijä), Chao Zhou (Tekijä), Hao-ran Liu (Tekijä), Lin-bo Liu (Tekijä), Jing-jing Tang (Tekijä), Xin-hua Xia (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

A new series of tertiary amine derivatives of chlorochalcone (4a∼4l) were designed, synthesized and evaluated for the effect on acetylcholinesterase (AChE) and buthylcholinesterase (BuChE). The results indicated that all compounds revealed moderate or potent inhibitory activity against AChE, and som...