Improved gene therapy for MFRP deficiency-mediated retinal degeneration by knocking down endogenous bicistronic Mfrp and Ctrp5 transcript

• मुख्य लेखकों: Xiao Tian (लेखक), Qingyun Zheng (लेखक), Jinyan Xie (लेखक), Qinlinglan Zhou (लेखक), Letong Liang (लेखक), Guotong Xu (लेखक), Hongyan Chen (लेखक), Chen Ling (लेखक), Daru Lu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The membrane frizzled-related protein (Mfrp) and C1-tumor necrosis factor related protein 5 (Ctrp5) genes are transcribed as a bicistronic unit and dysregulation of either gene is associated with retinal degeneration in the retinal pigment epithelium (RPE) cells. However, the mechanisms that regulat...