Improved gene therapy for MFRP deficiency-mediated retinal degeneration by knocking down endogenous bicistronic Mfrp and Ctrp5 transcript

• প্রধান লেখক: Xiao Tian (লেখক), Qingyun Zheng (লেখক), Jinyan Xie (লেখক), Qinlinglan Zhou (লেখক), Letong Liang (লেখক), Guotong Xu (লেখক), Hongyan Chen (লেখক), Chen Ling (লেখক), Daru Lu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2023-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The membrane frizzled-related protein (Mfrp) and C1-tumor necrosis factor related protein 5 (Ctrp5) genes are transcribed as a bicistronic unit and dysregulation of either gene is associated with retinal degeneration in the retinal pigment epithelium (RPE) cells. However, the mechanisms that regulat...