ORY-1001 Suppresses Cell Growth and Induces Apoptosis in Lung Cancer Through Triggering HK2 Mediated Warburg Effect

• Hauptverfasser: Zhaoliang Lu (Verfasst von), Yanke Guo (Verfasst von), Xiaoya Zhang (Verfasst von), Jing Li (Verfasst von), Leilei Li (Verfasst von), Shuai Zhang (Verfasst von), Changliang Shan (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

ORY-1001, an inhibitor of covalent lysine (K)-specific demethylase 1A (KDM1A), has been used as a therapy for the treatment of acute leukemia. However, the underlying mechanisms of anticancer are still not fully elucidated. Here, we report that KDM1A is highly expressed in lung cancers, where it app...