Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs

• Main Authors: Leonardo de Souza Teixeira (Author), Tatiana Vila Chagas (Author), Antonio Alonso (Author), Isabel Gonzalez-Alvarez (Author), Marival Bermejo (Author), James Polli (Author), Kênnia Rocha Rezende (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A major parameter controlling the extent and rate of oral drug absorption is permeability through the lipid bilayer of intestinal epithelial cells. Here, a biomimetic artificial membrane permeability assay (Franz-PAMPA Pampa) was validated using a Franz cells apparatus. Both high and low permeabilit...