Genetic polymorphisms in the endothelial nitric oxide synthase gene correlate with overall survival in advanced non-small-cell lung cancer patients treated with platinum-based doublet chemotherapy

• Main Authors: Mio Tadashi (Author), Kim Young (Author), Kaji Reiko (Author), Hata Akito (Author), Fukuhara Akiko (Author), Hatachi Yukimasa (Author), Masago Katsuhiro (Author), Fujita Shiro (Author), Mishima Michiaki (Author), Katakami Nobuyuki (Author)
• Format: Book
• Published: BMC, 2010-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Nitric oxide (NO) is a free radical that is involved in carcinogenesis. Endothelial NO, synthesized from L-arginine by endothelial NO synthase (eNOS), inhibits apoptosis and promotes angiogenesis, tumor cell proliferation and metasta...