Augmentation of EPR Effect and Efficacy of Anticancer Nanomedicine by Carbon Monoxide Generating Agents

• Main Authors: Jun Fang (Author), Rayhanul Islam (Author), Waliul Islam (Author), Hongzhuan Yin (Author), Vladimir Subr (Author), Tomas Etrych (Author), Karel Ulbrich (Author), Hiroshi Maeda (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One obstacle to the successful delivery of nanodrugs into solid tumors is the heterogeneity of an enhanced permeability and retention (EPR) effect as a result of occluded or embolized tumor blood vessels. Therefore, the augmentation of the EPR effect is critical for satisfactory anticancer nanomedic...