Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis

• Main Authors: Yasuhiro Watanabe (Author), Yasuhiro Kazuki (Author), Kanako Kazuki (Author), Mitsutaka Ebiki (Author), Mami Nakanishi (Author), Kazuomi Nakamura (Author), Miho Yoshida Yamakawa (Author), Hiroyuki Hosokawa (Author), Tetsuya Ohbayashi (Author), Mitsuo Oshimura (Author), Kenji Nakashima (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A human artificial chromosome (HAC) is maintained as an episome within a cell and avoids random integration into the host genome. It can transfer multiple and/or large transgenes along with their regulatory elements thereby resembling native chromosomes. Using this HAC system, we established mesench...