Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis

• मुख्य लेखकों: Yasuhiro Watanabe (लेखक), Yasuhiro Kazuki (लेखक), Kanako Kazuki (लेखक), Mitsutaka Ebiki (लेखक), Mami Nakanishi (लेखक), Kazuomi Nakamura (लेखक), Miho Yoshida Yamakawa (लेखक), Hiroyuki Hosokawa (लेखक), Tetsuya Ohbayashi (लेखक), Mitsuo Oshimura (लेखक), Kenji Nakashima (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2015-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A human artificial chromosome (HAC) is maintained as an episome within a cell and avoids random integration into the host genome. It can transfer multiple and/or large transgenes along with their regulatory elements thereby resembling native chromosomes. Using this HAC system, we established mesench...