Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities

• Hoofdauteurs: Jung-Chun Chu (Auteur), Hui-Ju Tseng (Auteur), Sung-Bau Lee (Auteur), Kai-Cheng Hsu (Auteur), Ling-Wei Hsin (Auteur), Ru-Hao Liang (Auteur), Tony Eight Lin (Auteur), Nain-Chu Gao (Auteur), Liang-Chieh Chen (Auteur), Wan-Hsun Lu (Auteur), Andrew H.-J Wang (Auteur), Wei-Jan Huang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Class II histone deacetylases (HDACs) are considered as potential targets to treat Alzheimer's disease (AD). Previously, C-3 substituted phenothiazine-containing compounds with class II HDAC-inhibiting activities was found to promote neurite outgrowth. This study replaced phenothiazine moiety w...