Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities

• Main Authors: Jung-Chun Chu (Author), Hui-Ju Tseng (Author), Sung-Bau Lee (Author), Kai-Cheng Hsu (Author), Ling-Wei Hsin (Author), Ru-Hao Liang (Author), Tony Eight Lin (Author), Nain-Chu Gao (Author), Liang-Chieh Chen (Author), Wan-Hsun Lu (Author), Andrew H.-J Wang (Author), Wei-Jan Huang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Class II histone deacetylases (HDACs) are considered as potential targets to treat Alzheimer's disease (AD). Previously, C-3 substituted phenothiazine-containing compounds with class II HDAC-inhibiting activities was found to promote neurite outgrowth. This study replaced phenothiazine moiety w...