Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway

• Glavni autori: Can Hu (Autor), Xin Zhang (Autor), Wenying Wei (Autor), Ning Zhang (Autor), Haiming Wu (Autor), Zhenguo Ma (Autor), Lingli Li (Autor), Wei Deng (Autor), Qizhu Tang (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2019-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant and anti-apoptotic capacities. Our present study aimed to investigate the effect of matrine on DOX-induced cardiotoxicity and...