Tenovin-1 Ameliorates Renal Fibrosis in High-Fat-Diet-Induced Diabetic Nephropathy via Antioxidant and Anti-Inflammatory Pathways

• Main Authors: Amit Kundu (Author), Sreevarsha Gali (Author), Swati Sharma (Author), Jae Hyeon Park (Author), So Young Kyung (Author), Sam Kacew (Author), In Su Kim (Author), Kwang Youl Lee (Author), Hyung Sik Kim (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-fat diet (HFD)-induced obesity has been involved in the development of diabetic nephropathy (DN). Tenovin-1, a potent selective SIRT1/2 inhibitor, regulates various target proteins. The present study evaluated the protective effect of Tenovin-1 against renal fibrosis in HFD-induced Zucker diabe...