Cyclodextrin Complexation as a Way of Increasing the Aqueous Solubility and Stability of Carvedilol

• Autors principals: Sébastien Rigaud (Autor), David Mathiron (Autor), Tarek Moufawad (Autor), David Landy (Autor), Florence Djedaini-Pilard (Autor), Frédéric Marçon (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2021-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

We studied the effect of several CDs on carvedilol's solubility and chemical stability in various aqueous media. Our present results show that it is possible to achieve a carvedilol concentration of 5 mg/mL (12.3 mM) in the presence of 5 eq of γCD or RAMEB in an aqueous medium with an acceptabl...