The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling

• প্রধান লেখক: Fangzhen Xia (লেখক), Ziteng Zhang (লেখক), Zhen Qian (লেখক), Xiaoyu Fang (লেখক), Junxue Wang (লেখক), Yan Wang (লেখক), Guoting Sun (লেখক), Yuefeng Yu (লেখক), Ninjian Wang (লেখক), Junke Zhen (লেখক), Yan Liu (লেখক), Yingli Lu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2025-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Objective: B7-H4 (B7S1, B7x, VTCN1) is an important immune checkpoint molecule that maintains immune homeostasis and is also expressed in pancreatic β cells. The polymorphism of B7-H4 influences the prevalence of Type 2 diabetes (T2D), suggesting a potential role of B7-H4 in the physiological functi...