The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling

• Main Authors: Fangzhen Xia (Author), Ziteng Zhang (Author), Zhen Qian (Author), Xiaoyu Fang (Author), Junxue Wang (Author), Yan Wang (Author), Guoting Sun (Author), Yuefeng Yu (Author), Ninjian Wang (Author), Junke Zhen (Author), Yan Liu (Author), Yingli Lu (Author)
• Format: Book
• Published: Elsevier, 2025-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: B7-H4 (B7S1, B7x, VTCN1) is an important immune checkpoint molecule that maintains immune homeostasis and is also expressed in pancreatic β cells. The polymorphism of B7-H4 influences the prevalence of Type 2 diabetes (T2D), suggesting a potential role of B7-H4 in the physiological functi...