The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling

• मुख्य लेखकों: Fangzhen Xia (लेखक), Ziteng Zhang (लेखक), Zhen Qian (लेखक), Xiaoyu Fang (लेखक), Junxue Wang (लेखक), Yan Wang (लेखक), Guoting Sun (लेखक), Yuefeng Yu (लेखक), Ninjian Wang (लेखक), Junke Zhen (लेखक), Yan Liu (लेखक), Yingli Lu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2025-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: B7-H4 (B7S1, B7x, VTCN1) is an important immune checkpoint molecule that maintains immune homeostasis and is also expressed in pancreatic β cells. The polymorphism of B7-H4 influences the prevalence of Type 2 diabetes (T2D), suggesting a potential role of B7-H4 in the physiological functi...