Sinomenine Attenuates Angiotensin II-Induced Autophagy via Inhibition of P47-Phox Translocation to the Membrane and Influences Reactive Oxygen Species Generation in Podocytes

• Main Authors: Weili Wang (Author), Juan Cai (Author), Sha Tang (Author), Ying Zhang (Author), Xuejing Gao (Author), Lijiao Xie (Author), Zhirong Mou (Author), Yuzhang Wu (Author), Li Wang (Author), Jingbo Zhang (Author)
• Format: Book
• Published: Karger Publishers, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Sinomenine, a pure alkaloid extracted from the Chinese medicinal plant Sinomenium acutum, and sinomenine hydrochloride (SN) has been successfully used for the therapy of rheumatoid arthritis (RA) and kidney diseases. Autophagy is a cytoprotective mechanism used by podocytes and othe...