Characterization of Sigma-2 Receptor-Specific Binding Sites Using [³H]DTG and [¹²⁵I]RHM-4

• Main Authors: Chi-Chang Weng (Author), Aladdin Riad (Author), Brian P. Lieberman (Author), Kuiying Xu (Author), Xin Peng (Author), John L. Mikitsh (Author), Robert H. Mach (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The sigma-2 receptor/transmembrane protein 97 (σ2R/TMRM97) is a promising biomarker of tumor proliferation and a target for cancer therapy. [³H]DTG has been used to evaluate σ2R/TMEM97 binding affinity in compound development studies. However, [³H]DTG ha...