Obesity Exacerbates Lupus Activity in Fc Gamma Receptor IIb Deficient Lupus Mice Partly through Saturated Fatty Acid-Induced Gut Barrier Defect and Systemic Inflammation

• Main Authors: Kanyarat Udompornpitak (Author), Awirut Charoensappakit (Author), Kritsanawan Sae-Khow (Author), Thansita Bhunyakarnjanarat (Author), Cong Phi Dang (Author), Wilasinee Saisorn (Author), Peerapat Visitchanakun (Author), Pornpimol Phuengmaung (Author), Tanapat Palaga (Author), Patcharee Ritprajak (Author), Somkanya Tungsanga (Author), Asada Leelahavanichkul (Author)
• Format: Book
• Published: Karger Publishers, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The prevalence of obesity is increasing, and the coexistence of obesity and systemic lupus erythematosus (lupus) is possible. A high-fat diet (HFD) was orally administered for 6 months in female 8-week-old Fc gamma receptor IIb deficient (FcgRIIb−/−) lupus or age and gender-matched wild-type (WT) mi...