Genetic and non‐genetic factors influencing efavirenz population pharmacokinetics among human immunodeficiency virus‐1‐infected children in Ethiopia

• Main Authors: Adugna Chala (Author), Eliford Ngaimisi Kitabi (Author), Jemal Hussien Ahmed (Author), Birkneh Tilahun Tadesse (Author), Tolossa Eticha Chaka (Author), Eyasu Makonnen (Author), Eleni Aklillu (Author)
• 格式: 图书
• 出版: Wiley, 2023-06-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Abstract Despite the potential for efavirenz (EFV) to be an effective alternative antiretroviral agent, its sources of wide inter‐ and intra‐individual pharmacokinetic (PK) variability are not well‐characterized in children. We investigated the effects of genetic and non‐genetic factors, including d...