Capsaicin mitigates ventilator-induced lung injury by suppressing ferroptosis and maintaining mitochondrial redox homeostasis through SIRT3-dependent mechanisms

• Hauptverfasser: Jinyuan Lin (Verfasst von), Huajin Ou (Verfasst von), Bijun Luo (Verfasst von), Maoyao Ling (Verfasst von), Fei Lin (Verfasst von), Liming Cen (Verfasst von), Zhaokun Hu (Verfasst von), Liu Ye (Verfasst von), Linghui Pan (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2024-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background Ventilator-induced lung injury (VILI) is one of the severe complications in the clinic concerning mechanical ventilation (MV). Capsaicin (CAP) has anti-inflammatory and inhibitory effects on oxidative stress, which is a significant element causing cellular ferroptosis. Neverthele...