Capsaicin mitigates ventilator-induced lung injury by suppressing ferroptosis and maintaining mitochondrial redox homeostasis through SIRT3-dependent mechanisms

• Main Authors: Jinyuan Lin (Author), Huajin Ou (Author), Bijun Luo (Author), Maoyao Ling (Author), Fei Lin (Author), Liming Cen (Author), Zhaokun Hu (Author), Liu Ye (Author), Linghui Pan (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ventilator-induced lung injury (VILI) is one of the severe complications in the clinic concerning mechanical ventilation (MV). Capsaicin (CAP) has anti-inflammatory and inhibitory effects on oxidative stress, which is a significant element causing cellular ferroptosis. Neverthele...