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TXNIP inhibition in the treatment of type 2 diabetes mellitus: design, synthesis, and biological evaluation of quinazoline derivatives

Thioredoxin interacting protein (TXNIP) is a potential drug target for type 2 diabetes mellitus (T2DM) treatment. A series of quinazoline derivatives were designed, synthesised, and evaluated to inhibit TXNIP expression and protect from palmitate (PA)-induced β cell injury. In vitro cell viability a...

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Bibliographic Details
Main Authors:	Aiyun Li (Author), Li Guan (Author), Wanzhen Su (Author), Ning Zhao (Author), Xuwen Song (Author), Jin Wang (Author), Xiaoxiao Tang (Author), Weize Li (Author), Xiangying Jiao (Author)
Format:	Book
Published:	Taylor & Francis Group, 2023-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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