Cover Image

A phase II multicenter randomized study to evaluate the safety and efficacy of combining thermotherapy and a short course of miltefosine for the treatment of uncomplicated cutaneous leishmaniasis in the New World.

<h4>Background</h4>Systemic pentavalent antimonials, mainly meglumine antimoniate, continue to be the first-choice drugs for treatment of cutaneous leishmaniasis (CL) despite their toxicity, difficulty of administration and high cost. In the search for therapeutic alternatives, combining...

Full description

Saved in:

Bibliographic Details
Main Authors:	Liliana López (Author), Braulio Valencia (Author), Fiorela Alvarez (Author), Ana Pilar Ramos (Author), Alejandro Llanos-Cuentas (Author), Juan Echevarria (Author), Iván Vélez (Author), Marina Boni (Author), Joelle Rode (Author), Juliana Quintero (Author), Alejandra Jiménez (Author), Yulied Tabares (Author), Claudia Méndez (Author), Byron Arana (Author)
Format:	Book
Published:	Public Library of Science (PLoS), 2022-03-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru.
by: Braulio M Valencia, et al.
Published: (2013)

Comprehensive economic evaluation of thermotherapy for the treatment of cutaneous leishmaniasis in Colombia
by: Jaiberth Antonio Cardona-Arias, et al.
Published: (2018)

Microwave Thermotherapy: New treatment for cutaneous leishmaniasis
by: Khalifa E. Sharquie, et al.
Published: (2015)

Successful treatment of multifocal cutaneous leishmaniasis with miltefosine
by: Bhushan Madke, et al.
Published: (2011)

Treatment of cutaneous leishmaniasis with thermotherapy in Brazil: an efficacy and safety study
by: Sheila Viana Castelo Branco Gonçalves, et al.
Published: (2018)

Use of miltefosine in the treatment of cutaneous leishmaniasis in French Guiana
by: Charlene Oliveira, et al.
Published: (2024)

Post-kala-azar dermal leishmaniasis developing in miltefosine-treated visceral leishmaniasis
by: Sankha Koley, et al.
Published: (2013)

A phase II study to evaluate the safety and efficacy of topical 3% amphotericin B cream (Anfoleish) for the treatment of uncomplicated cutaneous leishmaniasis in Colombia.
by: Liliana López, et al.
Published: (2018)

Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine.
by: Thomas P C Dorlo, et al.
Published: (2011)

Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.
by: Carolina Ferreira, et al.
Published: (2020)

Miltefosine for the treatment of cutaneous leishmaniasis-A pilot study from Ethiopia.
by: Saskia van Henten, et al.
Published: (2021)

Monitoring Cutaneous Leishmaniasis Lesions in Mice Undergoing Topical Miltefosine Treatment
by: Laura Fernanda Neira, et al.
Published: (2023)

Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial.
by: Monique Wasunna, et al.
Published: (2016)

Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients
by: Ayelet Ollech, et al.
Published: (2020)

Pharmacokinetic / pharmacodynamic relationships of liposomal amphotericin B and miltefosine in experimental visceral leishmaniasis.
by: Andrew A Voak, et al.
Published: (2021)

Comparison of cardiotoxicity between N-methyl-glucamine and miltefosine in the treatment of American cutaneous leishmaniasis
by: Daniel Holanda Barroso, et al.
Published: (2021)

Drug susceptibility in Leishmania isolates following miltefosine treatment in cases of visceral leishmaniasis and post kala-azar dermal leishmaniasis.
by: Vasundhra Bhandari, et al.
Published: (2012)

Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study.
by: Maria Del Mar Castro, et al.
Published: (2023)

The effect of oral miltefosine in treatment of antimoniate resistant anthroponotic cutaneous leishmaniasis: An uncontrolled clinical trial.
by: Masoumeh Tayyebi, et al.
Published: (2021)

Cost-effectiveness of meglumine antimoniate versus miltefosine caregiver DOT for the treatment of pediatric cutaneous leishmaniasis.
by: Brandon A Berger, et al.
Published: (2017)

Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial.
by: Paulo R Machado, et al.
Published: (2010)

Prediction score for antimony treatment failure in patients with ulcerative leishmaniasis lesions.
by: Cristian Valencia, et al.
Published: (2012)

Decline in Clinical Efficacy of Oral Miltefosine in Treatment of Post Kala-azar Dermal Leishmaniasis (PKDL) in India.
by: V Ramesh, et al.
Published: (2015)

A phase II, non-comparative randomised trial of two treatments involving liposomal amphotericin B and miltefosine for post-kala-azar dermal leishmaniasis in India and Bangladesh.
by: Shyam Sundar, et al.
Published: (2024)

Correction: Decline in Clinical Efficacy of Oral Miltefosine in Treatment of Post Kala-azar Dermal Leishmaniasis (PKDL) in India.
by: V Ramesh, et al.
Published: (2015)

In vitro and in vivo miltefosine susceptibility of a Leishmania amazonensis isolate from a patient with diffuse cutaneous leishmaniasis.
by: Adriano C Coelho, et al.
Published: (2014)

Quantification of Leishmania (Viannia) Kinetoplast DNA in Ulcers of Cutaneous Leishmaniasis Reveals Inter-site and Inter-sampling Variability in Parasite Load.
by: Milagros Suárez, et al.
Published: (2015)

The Therapeutic Potential of Chemo/Thermotherapy with Magnetoliposomes for Cancer Treatment
by: Alfonso Toro-Córdova, et al.
Published: (2022)

Leishmania RNA virus-1 is similarly detected among metastatic and non-metastatic phenotypes in a prospective cohort of American Tegumentary Leishmaniasis.
by: Braulio Mark Valencia, et al.
Published: (2022)

Safety and efficacy of short course combination regimens with AmBisome, miltefosine and paromomycin for the treatment of visceral leishmaniasis (VL) in Bangladesh.
by: Ridwanur Rahman, et al.
Published: (2017)

Risk factors for therapeutic failure to meglumine antimoniate and miltefosine in adults and children with cutaneous leishmaniasis in Colombia: A cohort study.
by: Maria Del Mar Castro, et al.
Published: (2017)

Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition.
by: Dimitri Bulté, et al.
Published: (2021)

In Vitro and In Vivo Miltefosine Susceptibility of a Leishmania amazonensis Isolate from a Patient with Diffuse Cutaneous Leishmaniasis: Follow-Up.
by: Adriano C Coelho, et al.
Published: (2016)

Histologic findings associated with laser interstitial thermotherapy for glioblastoma multiforme
by: J. Bradley Elder, et al.
Published: (2019)

The safety and efficacy of miltefosine in the long-term treatment of post-kala-azar dermal leishmaniasis in South Asia - A review and meta-analysis.
by: Joyce Pijpers, et al.
Published: (2019)

Direct comparison of the efficacy and safety of oral treatments with oleylphosphocholine (OlPC) and miltefosine in a mouse model of L. major cutaneous leishmaniasis.
by: Anny Fortin, et al.
Published: (2014)

Availability of miltefosine for the treatment of kala-azar in India
by: Shyam Sundar, et al.
Published: (2005)

Effects of cryotherapy and thermotherapy associated with static stretching on the flexibility of hamstring muscles
by: Simone Alves da Silva, et al.
Published: (2010)

Effects of cryotherapy and thermotherapy associated with static stretching on the flexibility of hamstring muscles
by: S.A. Silva, et al.
Published: (2010)

A randomized trial of AmBisome monotherapy and AmBisome and miltefosine combination to treat visceral leishmaniasis in HIV co-infected patients in Ethiopia.
by: Ermias Diro, et al.
Published: (2019)